“In a case-control study of testis cancer 259 cases with testicular cancer, 238 controls treated at radiotherapy centres and 251 non-radiotherapy hospital in-patient controls were interviewed about some possible prenatal and familial risk factors for the tumor.  For firstborn men, the risk of testis cancer increased significantly according to maternal age at the subject’s birth, and this effect was most marked for seminoma.  The association with maternal age was not apparent for cases other than firstborn.  The risk of testis cancer was also significantly raised for men from small sibships and of early birth order.  These results accord with the theory that raised maternal levels of available oestrogen during the early part of pregnancy are aetiological for testicular cancer in the son, although other explanations are possible; there is evidence that seminoma risk may particularly be affected.” (Swerdlow, A. J., Huttly, S. R., Smith, P. G. (1987) Prenatal and familial associations of testicular cancer.  Br J Cancer 55 (5):571)

A number of studies have emerged that connect birth order to enhanced likelihood of contracting specific diseases or conditions and increased hormone levels associated with those conditions.

A connection not made is that hormones, specifically testosterone, particularly the mother’s testosterone levels during pregnancy, influence maturation rates, and maturation rates reflect propensities for specific disease and condition tendencies in concert with established hormonal thresholds.

In addition, estrogen can be a powerful marker for testosterone proclivities in the context of those social structures that encourage specific testosterone-driven maturation rates.

In Classic Matrifocal social structure, high-testosterone, high-estrogen females will mate with low-testosterone, low-estrogen males.  Female breast cancer will be common in this population.

In Warrior Patrifocal social structure, high-testosterone, low-estrogen males will mate with low-testosterone, high-estrogen females.  High testicular and prostate cancer will be common.

Early puberty, or the maximal height achieved coming at a relatively young age, is also associated with higher rates of breast cancer.  This could be for several reasons.

Left-handed women get breast cancer a higher percentage of the time.  These would be the Classic Matrifocal.  They would be more accelerated in maturation rate, achieving puberty sooner.  In addition, they would menstruate a longer period of their lives, exposing them to higher levels of estrogen for longer periods.

High fat diets and alcohol consumption can increase female estrogen levels, adding to established tendencies.  Pubertal timing is influenced by diet.  Low fat diet can push back pubertal onset.

Combine genetic social structure tendency, uterine environment, pubertal timing as a result of maturation rates and diet, and environmental influences like diet, alcohol and exercise, and a picture emerges that can provide an idea of how changes in lifestyle can reduce the chances of cancer.


This entry was posted on Thursday, February 19th, 2009 at 6:30 am and is filed under Estrogen, Social Structure. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
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