June 18, 2009 | 6 Comments

Category: Causes of Autism, Estrogen, Ontogeny

OK.  Several possible estrogen-related connections have emerged in the last few days.

First, if estrogen is a trigger in teenaged girls for entering puberty, thus beginning the testosterone surges that freeze brain growth, and it is also true for males (a stretch) that estrogen levels trigger pubertal timing, might this also apply to male and female infant/toddler testosterone-surge synapse pruning that results in asymmetric cerebral lateralization?  If so, might infant/toddler estrogen levels be instrumental in causing autism, low estrogen resulting in delayed growth?

Second, noting the seeming connection between estrogen’s focus on the young and the exhibition of maternal behavior along with estrogen’s focus on very specific features in a mate (thus driving the emergence of unique male species traits), is it true that species that engage in female sexual selection are also species where the mother exhibits maternal behavior?  An implication is that K vs. r strategies might compel female choice and changes in the exhibition of male behaviors.

Third, might it be the case that estrogen, predating testosterone, is somehow responsible for early proliferation of life on earth insofar as estrogen is associated with creation, discrimination and focus on the young?

In the old religions, there is a view of life characterized by the triple symbol of virgin, mother and crone.  There are goddesses that are both creator and destroyer.  If we approach estrogen as contributing to the three hypothetical frames noted above, the female acquires a depth and power that is mythical in scope.

Estrogen nurtures the young.  Estrogen focuses on particular features in mates and then encourages the proliferation of those features over generations.  Whereas it seems like testosterone is deeply involved in the creative process, perhaps testosterone’s lack of discrimination places in the hands of the female the direction that evolution travels.

Whereas testosterone assigns the power, energy or speed with which evolution unfolds, estrogen governs creativity and direction.

The first two of the three premises noted above are testable hypotheses.  If it is discovered that species that engage in female choice also display maternal behavior, I’m not sure how useful that information is, except that it supports the dynamic I’m proposing regarding human social evolution.  It doesn’t prove anything.  If, indeed, estrogen is a trigger for pubertal timing in males and females, then estrogen may be the trigger for early childhood testosterone surges, which are integral to the timing of maturation changes.

If males that are naturally maturational delayed experience a further delay in the timing of testosterone surges, then Asperger’s or autism might result.

It just struck me that whereas low estrogen in girls approaching puberty delays pubertal onset, in males it might be reversed.  High estrogen in males might delay pubertal onset.

And there is the fact that I am an amateur.  I’m associating fat levels with estrogen levels.  The two may not be as closely related as I am assuming.

There are a lot of situations where male or female estrogen or testosterone levels go in opposite directions with the same environmental effects.  What if baby males need low estrogen to time testosterone surges and baby females need high estrogen to time those surges?

High-fat diets would result in males with increased likelihood of autism.


This entry was posted on Thursday, June 18th, 2009 at 7:04 am and is filed under Causes of Autism, Estrogen, Ontogeny. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
6 Comments so far

  1. mark on June 19, 2009 9:52 am

    Fat levels in males are tied to estrogen levels, e.g, the more body fat the higher the estrogen. Interesting post!

  2. Estrogen and Autism | Origins of Autism on July 16, 2009 1:08 pm

    […] autism. I’m not absolutely that is the case here, but there is that potential. But, as noted here and here, I’m playing with that […]

  3. Dao on January 18, 2012 9:54 am

    If you’re looking for the origins of Autism, then you have to understand that Autism is a scale upon which we all site.
    And also, that 75% of autistics are male, and there are ALWAYS higher levels testosterone in their umbilical blood (IE: measured when they were born).
    This it is an excess of uterine testosterone, not estrogen that causes autism.
    But for the bigger picture, you’ll have to read the website http://leftinthedark.org.uk/, as the picture is MUCH deeper than that.
    Lastly, phyto-estrogens from grains & beans, plus pseudo-estrogens in cosmetics, factory farming and fat cells are pushing them ever higher – but the primary result of this is a lack of genderization in all the research I have seen.

  4. monsterlegendshacksite.wordpress.com on October 27, 2015 1:38 pm

    By this point you can also be enjoyed by people I mean children that
    even a question. 5 gigabytes of capacity compared to already popular DS.

    And the same time, you may have missed like Zelda: Ocarina of Time in my
    youth and the fabric is almost realistic.

  5. Gebop on October 28, 2015 8:46 am






    精准医疗要做到个性、高效及预防的关键在于筛查和诊断,因此基因测序等检测诊断技术的发展是关键。成本的下降让基因测序商业化市场的打开成为可能,基因测序技术的成熟和商用经过了多年的发展,1980 年自动测序仪出现,2001 年完成了人类基因组框架图标志着这一技术的成熟,2007 年二代基因测序技术大幅降低测序成本,使得这一技术应用出现可能,以走在前列的Illumina 公司为例,该公司自2007 年起把当时每个基因组的测序成本费用从1000万美元降到了当下的1000 美元, 根据Illumina 公司数据,全球NGS(二代基因测序)的应用市场规模预计为200 亿美元,药品研发和临床应用是增速最快的领域,增速超过15%,肿瘤诊断和个性化用药是最有应用前景的领域,市场规模120亿美元。乐土投资与Illumina以及新一代的基因检测公司Genalyte, Centrillion都有着合作关系。


    全球创新论坛纽约峰会由全美华人金融协会(The Chinese Finance Association, TCFA) 主办。全美华人金融协会于一九九四年在美国成立。分布在世界各地的会员来自华尔街投行、基金、监管部门、和学术界,已成为联系中美金融界最重要的桥梁之一。协会定期举行学术年会。协会本部设在纽约,并在波士顿,华盛顿,旧金山,伦敦,香港,北京和上海等金融中心设有分会。


  6. how can i get free netflix on January 10, 2016 6:05 am

    I am truly delighted to glance at this website posts which consists of
    plenty of valuable information, thanks for providing these information.

Name (required)

Email (required)


Share your wisdom